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421 articles

Keyword: radiotherapyClear keyword

Bioengineering & translational medicine2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Combined HER2-targeted mRNA-LNP vaccine and radiotherapy suppress Lewis lung carcinoma growth in mice: Efficacy and mechanistic insights

Wang S, Jing S, Zou S, Zhang Y, Ge M, Gao K, Et Al.

HER2 overexpression is a pivotal oncogenic alteration in NSCLC and is associated with poor prognosis. Existing HER2-targeted therapeutics, including antibody-drug conjugates, have limited anticancer efficacy and prominent systemic toxicity, whereas radiotherapy-mediated tumor immunosuppression further hinders therapeutic outcomes.

HER2 Lewis lung carcinoma mRNA‐LNP vaccine radiotherapy tumor immune microenvironment

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