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Keyword: ribonucleoproteinClear keyword

Frontiers in genome editing2026ResearchNon-viral Gene Delivery

1. Genome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins

Yu Z, Li J, Liu M, Qi Q, Duan Z, Yang Z, Et Al.

Prime editing (PE) enables precise genome modifications without double-strand breaks, yet its application in large mammals has been hindered by low efficiency and the technical bottlenecks of zygote microinjection. This study aimed to establish a scalable PE platform in sheep via the direct electroporation of a PE3 RNP formulation comprising PE2 protein, an epegRNA, and a nicking sgRNA into zygotes.

genome editing prime editing ribonucleoprotein sheep zygote electroporation

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