Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era
Cm Jogdeo, K Siddhanta, A Das, L Ding, S Panja, N Kumari, D OupickýDOI 10.1002/adma.202404608
Summary
A review of polymer-based alternatives to lipid gene delivery, including polyplexes and polymer–nucleic acid conjugates, with attention to chemical tunability and clinical translation.
Keywords
Purpose: Polymer carriers offer a chemically tunable alternative to lipid systems for delivering nucleic acids.
Approach: The review surveys polymer design, polyplexes, covalent conjugates, computational methods and emerging clinical programmes.
Key findings: Tailoring polymer structure for specific nucleic acids and intracellular destinations may help overcome the limits of traditional polycations. The authors discuss translation efforts alongside newer computational design approaches.
Interpretation: Polymer chemistry expands the design space available for non-viral gene delivery.
Limitations: The evidence surveyed does not demonstrate that polymer carriers are generally superior to lipid nanoparticles in patients.
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