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Showing 1–1 of 1 articles · Keyword: Bispecific T-cell engager Clear keyword

International journal of biological macromolecules2026ResearchNon-viral Gene Delivery

1. Trophoblast cell-surface antigen 2-directed enhancement of gene delivery using a nanobody-engineered recombinant adeno-associated virus for bispecific T-cell engager-mediated T-cell cytotoxicity in triple-negative breast cancer cells

Shin Hg, Yang Hr, Hwang Jh, Cho Hr, Hwang K, Lee S

Triple-negative breast cancer (TNBC) poses a significant therapeutic challenge because it has limited actionable molecular targets. Trophoblast cell-surface antigen 2 (TROP2) is a promising therapeutic target, overexpressed in approximately 80% of TNBC cases. However, conventional recombinant adeno-associated virus…

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