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616 articles

Research Review

Showing 1–2 of 2 articles · Keyword: Triple-negative breast cancer Clear keyword

International journal of biological macromolecules2026ResearchNon-viral Gene Delivery

1. Trophoblast cell-surface antigen 2-directed enhancement of gene delivery using a nanobody-engineered recombinant adeno-associated virus for bispecific T-cell engager-mediated T-cell cytotoxicity in triple-negative breast cancer cells

Shin Hg, Yang Hr, Hwang Jh, Cho Hr, Hwang K, Lee S

Triple-negative breast cancer (TNBC) poses a significant therapeutic challenge because it has limited actionable molecular targets. Trophoblast cell-surface antigen 2 (TROP2) is a promising therapeutic target, overexpressed in approximately 80% of TNBC cases. However, conventional recombinant adeno-associated virus…

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Molecular pharmaceutics2026ResearchDrug Delivery

2. BBR-RHE Co-Loaded Nanoemulsion Potentiates Anti-PD-L1 Efficacy via Lipid Metabolic Reprogramming in Triple-Negative Breast Cancer

Wei J, Qian K, Shi J, Chen K, Zhang H, Gu M, Et Al.

Triple-negative breast cancer (TNBC) therapy is limited by the poor efficacy of anti-programmed death-ligand 1 (aPD-L1) monotherapy, with dysregulated lipid metabolism in the tumor microenvironment (TME) driving immunosuppression. Herein, a nanoemulsion co-loaded with berberine (BBR) and rhein (RHE) (BBR-RHE-NE), two…

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