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Showing 1–1 of 1 articles · Keyword: Cytoplasmic transport Clear keyword

Bioscience Reports2017ReviewNon-viral Gene Delivery

1. Cytoplasmic Transport and Nuclear Import of Plasmid DNA

Haiqing Bai, Gillian M. Schiralli Lester, Laura C. Petishnok, David A. Dean

Productive gene transfer requires plasmid DNA to not only enter cells but also traffic through the cytoplasm and cross the nuclear envelope. Most transfection strategies focus on membrane entry and promoter choice, but cytoplasmic trafficking and nuclear import are critical, rate-limiting barriers—especially because…

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