Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 25–27 of 27 articles · Keyword: Endocytosis Clear keyword

Molecular Membrane Biology1998ReviewNon-viral Gene Delivery

25. Cationic lipids, phosphatidylethanolamine and the intracellular delivery of polymeric, nucleic acid-based drugs (Review)

Hope Mj, Mui B, Ansell S, Ahkong Qf

Polymeric nucleic acid drugs—plasmid DNA, antisense oligonucleotides, and ribozymes—require protection from nucleases and efficient intracellular delivery to cytoplasm/nucleus. Viral vectors are efficient but immunogenic and safety-limited; non-viral cationic lipid systems are promising, but the mechanism of…

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Cellular Immunology1981ResearchNon-viral Gene Delivery

26. Endocytosis in Cytotoxic T-Lymphocytes

Hans-Jörg Heiniger, Arnold Sodergren, Jan D. Marshall

While pinocytosis (endocytosis) in lymphocytes had been qualitatively described using electron microscopy, quantitative measurements of endocytic activity and its relationship to immunological function were lacking. Understanding whether endocytosis correlates with T cell differentiation and cytotoxic function is…

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ResearchNon-viral Gene Delivery

27. Efficient gene delivery by EGF-lipoplexes in vitro and in vivo

Maria Buñuales, Nejat Düzgüneş, Sara Zalba, María J. Garrido & Conchita Tros De Ilarduya

Nonviral gene delivery vectors are safer than viral vectors but generally suffer from low and nonspecific transfection efficiency. EGFR is overexpressed on many tumour cells, making EGF-mediated targeting an attractive strategy to improve selectivity and gene delivery into cancer cells. EGF-lipoplexes were…

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