Papers, explained in our own words

1. Extracellular vesicle-based drug delivery in pediatric immune thrombocytopenia

Di Domenico O, Marrapodi Mm, Di Feo G, Argenziano L, Rossi F, Di Paola A

Pediatric immune thrombocytopenia (ITP) is an acquired immune-mediated disorder triggered by autoantibody production directed against glycoproteins on the platelet surface, leading to platelet destruction in the spleen and impaired megakaryopoiesis in the bone marrow. The immune response is further compromised by a…

• cell-free therapy
• drug delivery
• extracellular vesicles
• immune thrombocytopenia
• immunomodulation
• mesenchymal stromal cells

2. Mesenchymal stem cell-derived exosomes as nanocarriers for curcumin: from fundamental research to clinical translation

Pan Y, Wang R, Qin S, Zhao L, Xing X

Curcumin has diverse pharmacological activities but poor water solubility, rapid degradation, extensive metabolism, and very low oral bioavailability limit its therapeutic use. This review evaluates mesenchymal stem cell-derived exosomes (MSC-Exo; MSC-derived small extracellular vesicles per MISEV2023) as natural…

• Clinical translation
• Curcumin
• Extracellular vesicles
• GMP manufacturing
• Mesenchymal stem cell-derived exosomes
• Natural nanocarriers

3. Selecting Administration Routes for Therapeutic Extracellular Vesicles to Achieve Optimal Drug Delivery

Lee M, Choi Y, Yoon Sj, Kim M

Extracellular vesicles (EVs) have emerged as promising therapeutic carriers owing to their biocompatibility, low immunogenicity, and ability to transport diverse biological cargo. However, successful EV-based therapy depends not only on carrier engineering but also on selecting an administration route appropriate for…

• administration routes
• drug delivery
• extracellular vesicles

4. Extracellular vesicles as biomimetic platforms for photo-assisted cancer therapy: evolution from synthetic nanocarriers to engineered therapeutic systems

Beaugé L, Ibarra Le

Photo-assisted therapies have emerged as promising strategies for cancer treatment by combining localized tumor ablation with the induction of systemic antitumor immune responses. Despite encouraging preclinical and clinical advances, their therapeutic efficacy remains limited by the unfavorable pharmacokinetics…

• biomimetic drug delivery
• extracellular vesicles
• photo-assisted therapy
• photodynamic therapy
• theranostics
• tumor microenvironment

5. Coupling Extracellular Vesicles with Nanomedicine for Precision Theranostics

Kausar T, Ahmed W, Shafiq T, Kausar R, Liang Y, Duan L

Nanomedicine represents one of the pivotal technologies that further bridges critical gaps in precision theranostics through targeted delivery, integrated diagnostics and therapeutics, and personalized treatment. Among various nanocarriers, extracellular vesicles (EVs) have attracted substantial interest owing to…

• Clinical Translation
• Extracellular Vesicles
• Precision Theranostics
• Standardization
• Surface Modification
• Therapeutic Cargo Delivery

6. Macrophage-Based Nanoplatforms for Tumor-Targeted Drug Delivery and Cancer Immunomodulation: Extracellular Vesicles, Membrane-Coated Nanoparticles, and Live Cells

Li X, Yu Y, Xie Y, He P, Chen Y, Guo Z, Et Al.

Macrophages are highly plastic immune cells with tumor-homing capacity and immunomodulatory functions, making macrophage-based nanoplatforms attractive for cancer immunotherapy. Macrophage-based nanoplatforms include macrophage-derived extracellular vesicles (EVs), macrophage membrane-coated nanoparticles, and live…

• biomimetic nano-drug delivery systems
• enhanced permeability and retention effect
• extracellular vesicles
• immunomodulation
• macrophages
• tumor microenvironment

7. Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential

RNA interference (RNAi) therapeutics have shown potential for treating genetic, viral, and cancerous diseases, but the main bottleneck remains delivery of functional RNA molecules into the cell cytoplasm. The review focuses on liposomes and other lipid carriers, and on exosomes/extracellular vesicles (EVs), as…

• Liposomes
• Extracellular vesicles
• siRNA
• Transfection
• Lipid nanoparticle
• Endosomal escape
• Polymeric