Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

721 articles

Research Review

Showing 97–101 of 101 articles · Keyword: Gene delivery Clear keyword

Journal of Biological Chemistry1987ResearchNon-viral Gene Delivery

97. Internalization and Cycling of the T Cell Antigen Receptor - Role of Protein Kinase C

Yasuhiro Minami, Lawrence E. Samelson, Richard D. Klausner

The T cell antigen receptor (TCR) plays a critical role in T cell activation, but the dynamics of TCR internalisation and its regulation were poorly understood. It was known that phorbol esters (activators of protein kinase C) lead to loss of surface TCRs, but the mechanisms—whether internalisation was…

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Cellular Immunology1981ResearchNon-viral Gene Delivery

98. Endocytosis in Cytotoxic T-Lymphocytes

Hans-Jörg Heiniger, Arnold Sodergren, Jan D. Marshall

While pinocytosis (endocytosis) in lymphocytes had been qualitatively described using electron microscopy, quantitative measurements of endocytic activity and its relationship to immunological function were lacking. Understanding whether endocytosis correlates with T cell differentiation and cytotoxic function is…

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ResearchNon-viral Gene Delivery

99. Efficient gene delivery by EGF-lipoplexes in vitro and in vivo

Maria Buñuales, Nejat Düzgüneş, Sara Zalba, María J. Garrido & Conchita Tros De Ilarduya

Nonviral gene delivery vectors are safer than viral vectors but generally suffer from low and nonspecific transfection efficiency. EGFR is overexpressed on many tumour cells, making EGF-mediated targeting an attractive strategy to improve selectivity and gene delivery into cancer cells. EGF-lipoplexes were…

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ResearchNon-viral Gene Delivery

100. pH-Responsive Polydopamine Nanoparticles for Photothermally Promoted Gene Delivery

Peng Zhang, Qinan Xu, Xinfang Li, Youxiang Wang

Non-viral gene vectors must overcome multiple extracellular and intracellular barriers: stability in blood, efficient cellular uptake, endosomal escape, and intracellular gene release. Stimuli-responsive carriers can address some barriers, but a carrier capable of overcoming multiple barriers simultaneously is still…

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ResearchDrug Delivery

101. Synthesis and Characterization of Acetalated Dextran Polymer and Microparticles with Ethanol as a Degradation Product

Kevin J. Kauffman, Clement Do, Sadhana Sharma, Matthew D. Gallovic, Eric M. Bachelder, Kristy M. Ainslie

Acetalated dextran (Ac-DEX) is a pH-sensitive, biodegradable polymer useful for drug delivery, but it degrades to methanol, which can be toxic at high concentrations or with repeated dosing. A safer analog that degrades to ethanol instead of methanol is needed for high-volume clinical applications such as multiple…

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