Papers, explained in our own words

1. Degradable Polymer-Coated Gold Nanoparticles for Co-Delivery of DNA and siRNA

Corey J. Bishop, Stephany Y. Tzeng, Jordan J. Green

There is a need for improved nanobiotechnologies that enable intracellular delivery of difficult-to-deliver biologics such as nucleic acids. Ideally, a delivery material should deliver both large molecules such as DNA and small molecules such as siRNA—enabling both positive and negative regulation of genes—while being non-cytotoxic and capable of imaging/theranostic multifunctionality. Gold nanoparticles (AuNPs) are attractive cores due to their. Particle size: CAu = 23 ± 1 nm; MAu = 27 ± 2 nm; layered particles reached ~200 nm. Largest increase at DNA layer (~230 nm). - Zeta potential: Reversed charge with each polyelectrolyte layer, confirming successful LbL.