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Research Review

Showing 1–1 of 1 articles · Keyword: IL-12 Clear keyword

Pharmaceutics2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Bench-to-Bedside Development of IMNN-001: A Non-Viral IL-12 Gene Therapy for Advanced Ovarian Cancer

Anwer K, Sood S, Sparks J, Faller Dv, Limon A, Lindborg Sr

Interleukin-12 (IL-12) is a potent immunostimulatory cytokine with well-established antitumor activity, but systemic recombinant IL-12 administration has been constrained by inflammatory toxicity, high circulating cytokine peaks, and insufficient tumor-local exposure. IMNN-001 is a non-viral IL-12 gene therapy…

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