Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–2 of 2 articles · Keyword: ovarian cancer Clear keyword

International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Ovarian Cancer Nanovaccines: Recent Strategic Advances from Antigen Selection to Carrier Design

Tang X, Huang Y, Zhang X, He C

Ovarian cancer is one of the most lethal gynecological malignancies. Its immunosuppressive tumor microenvironment and peritoneal dissemination characteristics have severely limited the efficacy of existing immunotherapies. To overcome the poor immunogenicity of tumor antigens and the need for coordinated delivery of…

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Pharmaceutics2026ReviewNon-viral Gene DeliveryDrug Delivery

2. Bench-to-Bedside Development of IMNN-001: A Non-Viral IL-12 Gene Therapy for Advanced Ovarian Cancer

Anwer K, Sood S, Sparks J, Faller Dv, Limon A, Lindborg Sr

Interleukin-12 (IL-12) is a potent immunostimulatory cytokine with well-established antitumor activity, but systemic recombinant IL-12 administration has been constrained by inflammatory toxicity, high circulating cytokine peaks, and insufficient tumor-local exposure. IMNN-001 is a non-viral IL-12 gene therapy…

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