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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

586 articles

Research Review

Showing 1–2 of 2 articles · Keyword: MT: delivery strategies Clear keyword

Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

1. LNP-mediated CRISPR gene editing of human vascular endothelial cells in 2D and 3D microfluidic cell culture systems

Olsen Al, Brandt Cbv, Larsen Rk, Fonager Sv, Zubia-Aranburu J, Haskó J, Et Al.

Efficient and cell-type-specific delivery remains a major barrier to CRISPR-based genome editing in vascular endothelial cells. Here, we systematically evaluate lipid nanoparticle (LNP)-mediated mRNA and CRISPR delivery in human umbilical vein endothelial cells (HUVECs). While a conventional SM-102-based LNP…

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Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

2. Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles

Ramamurthy A, Scimonelli G, Murphy Wl, Saha K

Human T cells modified with nucleic acids constitute a powerful and emerging therapeutic modality for cancer, autoimmune disorders, and aging-related diseases. However, delivering nucleic acids, such as mRNA encoding synthetic receptors, transcription factors, cytokines, or genome editors to T cells can be…

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