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571 articles

Research Review

Showing 1–1 of 1 articles · Keyword: MyD88 Clear keyword

Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

1. cGAS-mediated immunogenicity impairs the stability and safety of LNP-encapsulated DNA in vivo

Wang X, Liu T, Long B, Li M, Yao Y, Fu Y, Et Al.

DNA-based non-viral gene therapy offers a promising platform for titratable gain-of-function treatments, enabling multi-dosing and sustained efficacy. However, its clinical translation has been constrained by unintended immune activation. We systematically investigated the pathogenesis of DNA drug-induced toxicity in…

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