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Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–2 of 2 articles · Keyword: toxicity Clear keyword

European journal of medicinal chemistry2026ReviewDrug Delivery

1. Metal-organic frameworks for cancer drug delivery: Molecular design, therapeutic mechanisms, safety, and clinical translation

Alahmary La, Sukkarieh Fa, Ferdous Ut, Helal A, Uddin S

Metal-organic frameworks (MOFs) are tuneable porous platforms for cancer drug delivery, as their metal nodes, organic linkers, pore architecture, and surface chemistry can be engineered to control cargo loading, targeting, degradation, and stimulus-responsive release. This review critically discusses the…

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Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

2. cGAS-mediated immunogenicity impairs the stability and safety of LNP-encapsulated DNA in vivo

Wang X, Liu T, Long B, Li M, Yao Y, Fu Y, Et Al.

DNA-based non-viral gene therapy offers a promising platform for titratable gain-of-function treatments, enabling multi-dosing and sustained efficacy. However, its clinical translation has been constrained by unintended immune activation. We systematically investigated the pathogenesis of DNA drug-induced toxicity in…

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