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406 articles

Keyword: Pulmonary mRNA deliveryClear keyword

Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery

Nasr Ss, Tabah Oe, Kumar S, Poore S, Duncan Ga

Pulmonary delivery of lipid nanoparticles (LNPs) remains an area of significant interest, given the broad range of genetic disorders that could be addressed through localized administration of therapeutic nucleic acids to the lung. In this study, we investigated how incorporation of the clinically used lung surfactant cocktail Poractant alfa affects the in vitro and in vivo transfection performance of mRNA-loaded LNPs.

Endosomal escape Lipid nanoparticles Poractant-alpha Pulmonary mRNA delivery

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