1. Bioactivatable conjugated nanocarriers for synergistic mRNA-mediated cancer immunotherapy
Nazir N, Gajjar Tb, Hanumanthayya M, Bainsal N, Singhal D, Smerat A, Et Al.
mRNA immunotherapy holds transformative potential in oncology, yet single-agent approaches frequently fail against immunosuppressive tumor microenvironments (TMEs). Bioactivatable co-delivery of immunogenic chemotherapy alongside mRNA offers mechanistically synergistic advantages, yet coformulation of hydrophobic…
- Immunogenic cell death
- Lipid nanoparticles
- ROS-responsive prodrug
- Tumor microenvironment
- cGAS-STING
- mRNA cancer vaccine
