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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

421 articles

Keyword: dual targetingClear keyword
ACS applied bio materials2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Reactive Polymer-Engineered Dual-Targeting Fluorescent Lipid Nanoparticles for Enhanced saRNA Delivery

Wang W, Liu H, Tang W, Shin J, Kim Yc, Li S

Lipid nanoparticles (LNPs) are widely explored as delivery vehicles for self-amplifying RNA (saRNA); however, incorporation of surface functionalities, such as fluorescent dyes for imaging and ligands for targeted delivery, remains challenging. In this study, we introduce a reactive poly(pentafluorophenyl acrylate) (PPFPA)-based copolymer platform containing a terminal C12 alkyl chain for LNP incorporation and reactive sites for modular conjugation of near-infrared dye IR775, targeting peptides, and polyethylene glycol chains.

dual targetingfluorescence imaginglipid nanoparticlesreactive polymerself-amplifying RNA
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