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421 articles

Keyword: self-amplifying RNAClear keyword
ACS applied bio materials2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Reactive Polymer-Engineered Dual-Targeting Fluorescent Lipid Nanoparticles for Enhanced saRNA Delivery

Wang W, Liu H, Tang W, Shin J, Kim Yc, Li S

Lipid nanoparticles (LNPs) are widely explored as delivery vehicles for self-amplifying RNA (saRNA); however, incorporation of surface functionalities, such as fluorescent dyes for imaging and ligands for targeted delivery, remains challenging. In this study, we introduce a reactive poly(pentafluorophenyl acrylate) (PPFPA)-based copolymer platform containing a terminal C12 alkyl chain for LNP incorporation and reactive sites for modular conjugation of near-infrared dye IR775, targeting peptides, and polyethylene glycol chains.

dual targetingfluorescence imaginglipid nanoparticlesreactive polymerself-amplifying RNA
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