Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–2 of 2 articles · Keyword: systemic delivery Clear keyword

Molecular therapy. Advances2026ReviewNon-viral Gene Delivery

1. Stealthy lentiviral vectors: Breaking the barriers to systemic in vivo gene delivery

Keating Al, Carlisle Rc, Mitrophanous Ka, Seymour Lw, Fisher Kd

Lentiviral vector (LVV)-mediated chimeric antigen receptor (CAR)-T cell therapy has transformed the landscape for blood cancer treatment through genetic modification of patients' T cells. Yet, the complexity of the manufacturing process makes this therapy inaccessible for many patients. Systemic intravenous delivery…

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Expert opinion on drug delivery2026ReviewNon-viral Gene DeliveryDrug Delivery

2. siRNA therapeutics: from hepatic delivery to extrahepatic targeting

Wang N, Meng L, Shi Jx, Bartneck M

Small interfering RNA (siRNA) has progressed from an experimental gene-silencing tool to an established therapeutic modality through advances in chemical modification and delivery. Lipid nanoparticles (LNP) and N-acetylgalactosamine (GalNAc)-siRNA conjugates have driven this clinical translation, particularly for…

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