Articles

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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 49–50 of 50 articles · Keyword: mRNA Clear keyword

Journal of Controlled Release2010ResearchNon-viral Gene Delivery

49. Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

IL-12 gene therapy is attractive for cancer because local IL-12 expression can prime anti-tumour immunity while reducing systemic toxicity. However, non-viral gene delivery to tumours is inefficient, and simple sonoporation using ultrasound alone does not achieve sufficient cancer gene therapy. The authors tested…

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Proceedings of the National Academy of Sciences1989ResearchNon-viral Gene Delivery

50. Cationic liposome-mediated RNA transfection

Malone Rw, Felgner Pl, Verma Im

RNA transfection was inefficient and restricted because intact RNA was difficult to obtain and rapidly degraded. In vitro transcription could now supply large amounts of RNA, creating a need for a reliable method to introduce RNA into cells and study translational efficiency and mRNA stability. Transfection of 10 ng…

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