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Research Review

Showing 1–1 of 1 articles · Keyword: pMMR/MSS Clear keyword

Molecular cancer2026ResearchNon-viral Gene DeliveryDrug Delivery

1. siRNA-mediated mismatch repair disruption synergizes with oxaliplatin to restore immune surveillance in microsatellite-stable colorectal cancer

Ni J, He G, Wang H, Qin Y, Guo J, Wang Y, Et Al.

Proficient mismatch repair/microsatellite-stable colorectal cancer (pMMR/MSS CRC), which represents the majority of clinical cases, exhibits low tumor mutational burden and minimal responsiveness to immune checkpoint blockade. Disrupting the MMR system has been shown to resensitize pMMR/MSS CRC to immune…

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