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586 articles

Research Review

Showing 1–1 of 1 articles · Keyword: quantitative systems pharmacology (QSP) Clear keyword

Expert review of clinical pharmacology2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Mathematical modeling in mRNA therapeutics: towards a pathway to individualized treatment protocols

Campanile E, Pettinà E, Marchetti L

mRNA-lipid nanoparticle (mRNA-LNP) therapeutics represent a transformative pharmacological paradigm in which the delivery vehicle, genetic payload, and expressed protein form a tightly coupled system. This multicomponent structure introduces nonlinear, multiscale dynamics that challenge traditional pharmacokinetic…

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