Frontiers in pharmacology2026ReviewNon-viral Gene DeliveryDrug Delivery
1. Targeted delivery platforms for in vivo immune cell engineering: emerging strategies for cancer immunotherapy
Rachamala Hk, Atla S, Angom Rs
Cancer immunotherapy is a transformative technology allowing for the elimination of malignant cells through immune system stimulation; however, the large-scale clinical application of adoptive cellular therapy technologies is limited due to difficulties in ex vivo immune cell engineering, high costs, and complicated manufacturing process. Recently, in vivo immune cell engineering was discovered as an emerging approach that allows for the genetic reprogramming of immune cells in patients, thus circumventing many problems inherent to traditional cellular therapy technologies.
In vivo immune cell engineeringcancer immunotherapychimeric antigen receptor (CAR) therapylipid nanoparticlesmRNA therapeuticstargeted delivery
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