Biotechnology journal2026ResearchNon-viral Gene Delivery
1. Comparison of Wildtype and Recombinant Adeno-Associated Virus (AAV) Production Reveals Distinct Productivity and Content Ratio Profiles
Alfieri S, Lee Kh
Recombinant adeno-associated virus is a leading viral vector for gene therapy. However, recombinant adeno-associated virus production systems have low titer and content ratio (ratio of genome-containing to total adeno-associated virus capsids), making it difficult to generate the large number of vector genomes…
- content ratio
- gene therapy
- recombinant adeno‐associated virus (rAAV)
- transient transfection
- viral vector manufacturing
- wildtype AAV infection
