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What is happening at Brilliant Blue — and around it

Company Updates covers news from Brilliant Blue Biosciences. Research & Industry News highlights relevant developments published by external sources, summarised and attributed to them.

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Engineered mRNA system enables cell-selective gene expression

SMRTS is a “smart” mRNA system that switches therapeutic genes on or off depending on cell type, enabling targeted cancer treatments while expanding the mRNA toolbox for precision medicine applications. The post Engineered mRNA System Delivers SMRTS for Cell-Selective Gene Expression appeared first on GEN - Genetic Engineering and Biotechnology News. The report concerns nonviral delivery, nanocarrier development, formulation, or translation; it does not by itself establish clinical benefit.

Source: GEN — Genetic Engineering & Biotechnology News

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Microfluidics produces consistent polymer-containing lipopolyplexes

A two-step microfluidics system created ternary nano-scale lipopolyplexes, using polymer choice to determine the lipopolyplexes’ structure, which affects vector size and distribution. This overcomes barriers to manufacturing and creates nonviral vectors for efficient DNA delivery. The post Microfluidics-Manufactured Lipopolyplexes Offer Size Consistency appeared first on GEN - Genetic Engineering The report concerns nonviral delivery, nanocarrier development, formulation, or translation; it does not by itself establish clinical benefit.

Source: GEN — Genetic Engineering & Biotechnology News

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Lonza to scale RION's exosome manufacturing

The agreement supports larger-scale production of RION's platelet-derived exosome therapeutics using the company's manufacturing platform. The announcement concerns a product, collaboration or production plan; it does not by itself establish clinical benefit or verified scale-up performance.

Source: GEN — Genetic Engineering & Biotechnology News

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Collaboration advances personalised mRNA-based CRISPR therapy

A close partnership between academic institutions, industry, and the FDA is necessary for success in manufacturing personalised treatment. That’s a key message behind a talk at BPI this week, presented by Max Sellman of Aldevron. The post Collaboration Key to First Personalised mRNA-based CRISPR Therapy appeared first on GEN - Genetic Engineering and Biotechnology News. The report concerns nonviral delivery, nanocarrier development, formulation, or translation; it does not by itself establish clinical benefit.

Source: GEN — Genetic Engineering & Biotechnology News

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Scientists just made CRISPR three times more effective

Northwestern scientists have developed a new nanostructure that supercharges CRISPR’s ability to safely and efficiently enter cells, potentially unlocking its full power to treat genetic diseases. By wrapping CRISPR’s tools in spherical DNA-coated nanoparticles, researchers tripled gene-editing success rates, improved precision, and dramatically reduced toxicity compared to current methods.

Source: ScienceDaily

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