Papers, explained in our own words

1. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies

Bhardwaj A

Off-target activity remains a significant challenge in the clinical development of CRISPR-based therapies. As programmable nucleases advance from experimental tools toward approved medicines, the ability to predict, detect, and mitigate unintended genomic editing events has acquired direct translational importance.

• Base editing
• CRISPR-Cas systems
• Epigenome editing
• Gene therapy
• Genome editing
• Guide RNA design
• High-fidelity Cas9
• Off-target effects
• Prime editing
• Structural variation