Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–5 of 5 articles · Keyword: Genome editing Clear keyword

Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

1. LNP-mediated CRISPR gene editing of human vascular endothelial cells in 2D and 3D microfluidic cell culture systems

Olsen Al, Brandt Cbv, Larsen Rk, Fonager Sv, Zubia-Aranburu J, Haskó J, Et Al.

Efficient and cell-type-specific delivery remains a major barrier to CRISPR-based genome editing in vascular endothelial cells. Here, we systematically evaluate lipid nanoparticle (LNP)-mediated mRNA and CRISPR delivery in human umbilical vein endothelial cells (HUVECs). While a conventional SM-102-based LNP…

Read the article

Frontiers in genome editing2026ReviewNon-viral Gene Delivery

2. CRISPR/Cas genome editing strategies to enhance abiotic stress tolerance in sugar crops

Liu Hb, Kumar T, Abu-Ellail Ffb, Lin Xq, Li Cj, Xu Ch, Et Al.

Sugar crops including sugarcane, sugar beets, and sweet sorghum, are fundamental for global sucrose supply and crucial feedstocks for bioethanol production and industrial bioproducts. However, yield and sucrose accumulation are significantly influenced by abiotic stresses, including drought, salinity/alkalinity…

Read the article

Theranostics2026ReviewNon-viral Gene DeliveryDrug Delivery

3. Recent advances in CRISPR technologies for biomedical applications and disease treatment

Wu X, Kou X, Bai L, Liu C, Wu Q, Zhang M, Et Al.

Clustered regularly interspaced short palindromic repeats (CRISPR), a precise genome-editing platform, has revolutionized genetic engineering. The highly selective and programmable characteristics of CRISPR have enabled its broad application. Recent advances in CRISPR biotechnology have promoted its widespread use in…

Read the article

Discover genetics and evolution2026ReviewNon-viral Gene Delivery

4. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies

Bhardwaj A

Off-target activity remains a significant challenge in the clinical development of CRISPR-based therapies. As programmable nucleases advance from experimental tools toward approved medicines, the ability to predict, detect, and mitigate unintended genomic editing events has acquired direct translational importance.

Read the article

Frontiers in genome editing2026ResearchNon-viral Gene Delivery

5. Genome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins

Yu Z, Li J, Liu M, Qi Q, Duan Z, Yang Z, Et Al.

Prime editing (PE) enables precise genome modifications without double-strand breaks, yet its application in large mammals has been hindered by low efficiency and the technical bottlenecks of zygote microinjection. This study aimed to establish a scalable PE platform in sheep via the direct electroporation of a PE3…

Read the article

Let's engineer the next delivery breakthrough together

We co-develop nanocarrier and biosensing programmes with pharma, biotech and academic groups — from target selection through scale-up.

ResearchersRequest a technical consultationTalk formulation, characterisation or assay design with one of our scientists.Industry partnersExplore co-developmentFeasibility studies, co-development programmes and licensing.InvestorsExplore the market opportunitySourced market sizes, pipeline, investment and deal data for genetic medicine delivery.