International journal of biological macromolecules2026ResearchDrug Delivery
1. Hydrophobicity-tuned oleic acid-functionalized chitosan nanoparticles for sustained ocular delivery of dapagliflozin in diabetic cataract
Lin Zi, Yeh Tc, Sun Gc, Chen Yy, Cheng Pw
Chitosan-based biological macromolecules provide a versatile platform for ocular drug delivery, but their hydrophilic nature limits the encapsulation and sustained release of hydrophobic therapeutics. Here, we designed oleic acid-functionalized chitosan nanoparticles (OA-CS NPs) with tunable hydrophobicity by varying…
- Chitosan
- Dapagliflozin
- Diabetic cataract
- Epithelial–mesenchymal transition
- Nanoparticles
- Ocular drug delivery
