Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

721 articles

Research Review

Showing 1–4 of 4 articles · Keyword: Dendritic cells Clear keyword

International Journal of Pharmaceutics2018ReviewNon-viral Gene Delivery

1. Nanoparticles for dendritic cell-based immunotherapy

Tran Th, Tran Ttp, Nguyen Ht, Phung Cd, Jeong J-H, Stenzel Mh, Jin Sg, Yong Cs, Truong Dh, Kim Jo.

Dendritic cell (DC)-based cancer immunotherapy is promising but limited by poor antigen immunogenicity, weak stability, and short in vivo half-life. Nanotechnology can protect antigens and adjuvants from premature degradation, enhance delivery to DCs, and improve therapeutic T cell responses. This review summarises…

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Current Opinion in Lipidology2012ReviewNon-viral Gene Delivery

2. Lipid-based carriers of microRNAs and intercellular communication

Vickers Kc, Remaley At

Extracellular miRNAs are unusually stable in plasma and their circulating levels change with disease, making them promising biomarkers. They are associated with lipid-based carriers—exosomes, microvesicles, apoptotic bodies, and lipoproteins—as well as lipid-free proteins. Whether these carriers mediate functional…

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Advanced Drug Delivery Reviews2005ReviewNon-viral Gene Delivery

3. PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines

Ying Waeckerle-Men And Marcus Groettrup

Dendritic cell (DC)-based vaccines are limited by the short persistence of MHC class I/peptide complexes on the DC surface—often only a few hours—when soluble peptides are loaded exogenously. This short presentation limits CTL activation and vaccine efficacy. The authors investigated biodegradable PLGA microspheres…

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Trends in Immunology2002ReviewNon-viral Gene Delivery

4. Caveolae and Caveolin in Immune Cells: Distribution and Functions

James Harris, Dirk Werling, Jayne C. Hope, Geraldine Taylor, Chris J. Howard

Caveolae and caveolin are cholesterol-rich membrane microdomains involved in endocytosis, cholesterol regulation, and signal transduction, but their presence and function in immune cells have been contentious. This review addresses the need to clarify the distribution and roles of caveolae/caveolin in mammalian…

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