Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

391 articles

Keyword: Magnetic nanoparticlesClear keyword

Frontiers in Immunology2021ReviewNon-viral Gene Delivery

1. Nanoparticles for Enhanced Adoptive T Cell Therapies and Future Perspectives for CNS Tumors

Balakrishnan Pb, Sweeney Ee.

Adoptive T cell therapy has revolutionized treatment of some hematologic malignancies but remains limited in solid tumors—especially central nervous system (CNS) tumors—by poor intratumoral delivery across anatomical barriers, suboptimal T cell specificity or activation, and intratumoral T cell dysfunction caused by immunosuppressive tumor microenvironments. Nanoparticles may overcome these limitations by improving ex vivo T cell manufacture. Representative findings from cited studies: - Nanostructured PEG hydrogels with anti-CD3-conjugated gold nanoparticles enabled T cell activation, proliferation, and memory. - Immunoliposomes targeting CD90 delivered a.

T cells Nanoparticles CAR-T cells Liposomes Lipid nanoparticle Magnetic nanoparticles Polymeric

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ACS Applied Materials & Interfaces2020ResearchNon-viral Gene Delivery

2. Cationic Nanoparticle-Mediated Activation of Natural Killer Cells for Effective Cancer Immunotherapy

Kwang-Soo Kim, Jun-Hyeok Han, Seung Hee Choi, Hae-Yun Jung, Joo Dong Park, Hee-Jung An, Seong-Eun Kim, Dong-Hyun Kim, Junsang Doh, Dong Keun Han, Ik-Hwan Kim, Wooram Park, Kyung-Soon Park

Natural killer (NK) cells are promising for cancer immunotherapy due to their lower risk of cytokine storm and graft-versus-host disease compared to T cell therapies. However, existing NK cell activation strategies—genetic engineering and cytokine treatment—are inefficient, expensive, and involve complex processing. A facile, one-step method to activate NK cells without genetic modification or exogenous cytokines is needed. ### Nanoparticle Characterization | Parameter | PDA-NPs | cNPs (PEI-coated) | aNPs (anionic control) | |---------------|-------------|----------------------|---------------------------| | Diameter | 38 nm | 41 nm | Not.

Cancer immunotherapy Natural killer cells Nanoparticles Polyethylenimine Polymeric Magnetic nanoparticles T cells

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