1. Cationic Nanoparticle-Mediated Activation of Natural Killer Cells for Effective Cancer Immunotherapy
Kwang-Soo Kim, Jun-Hyeok Han, Seung Hee Choi, Hae-Yun Jung, Joo Dong Park, Hee-Jung An, Seong-Eun Kim, Dong-Hyun Kim, Junsang Doh, Dong Keun Han, Ik-Hwan Kim, Wooram Park, Kyung-Soon Park
Natural killer (NK) cells are promising for cancer immunotherapy due to their lower risk of cytokine storm and graft-versus-host disease compared to T cell therapies. However, existing NK cell activation strategies—genetic engineering and cytokine treatment—are inefficient, expensive, and involve complex processing. A facile, one-step method to activate NK cells without genetic modification or exogenous cytokines is needed. ### Nanoparticle Characterization | Parameter | PDA-NPs | cNPs (PEI-coated) | aNPs (anionic control) | |---------------|-------------|----------------------|---------------------------| | Diameter | 38 nm | 41 nm | Not.