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571 articles

Research Review

Showing 1–1 of 1 articles · Keyword: Negatively charged LNPs Clear keyword

Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Rationally designed negatively charged lipid nanoparticles reduce systemic reactogenicity of mRNA vaccines while preserving immunogenicity

Karaki T, Inoue W, Gis T, Shichinohe S, Watanabe T, Hirai T, Et Al.

Messenger RNA (mRNA) vaccines have emerged as versatile platforms for the prevention of infectious diseases and therapeutic cancer vaccination. However, strong reactogenicity remains a key challenge, with severe adverse events such as myocarditis. These concerns may limit the applications of mRNA vaccines. As lipid…

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