Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 1–5 of 5 articles · Keyword: mRNA vaccines Clear keyword

International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Nanocarrier-Mediated Immunotherapy for Gynecological Malignancies: Mechanisms, Clinical Translation, and Emerging Nucleic Acid-Based Strategies

Fu M, Zhao R, Cao Y, Nan Y, Fan L, Liu Z

Gynecological cancers, including ovarian, cervical, and endometrial cancers, remain major contributors to female morbidity and mortality worldwide. Conventional treatments-surgery, chemotherapy, and radiotherapy-have improved outcomes, but advanced or recurrent disease is still associated with poor prognosis…

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Acta pharmaceutica Sinica. B2026ResearchNon-viral Gene DeliveryDrug Delivery

2. Targeting cancer-associated neutrophils with biomimetic nano-vaccines loaded with mRNA can enhance the efficacy of immunotherapy for hepatocellular carcinoma

Li S, Zhang Y, Han Y, Zhao M, Wang Y, Lu J, Et Al.

Neutrophils exhibit significant plasticity within the tumor microenvironment (TME), such as promoting immune suppression, tumor growth, and metastasis. Although various nano drug delivery systems targeting neutrophils have been developed based on their tumor chemotaxis, few studies have focused on designing…

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European journal of haematology2026ReviewNon-viral Gene DeliveryDrug Delivery

3. Beyond Dendritic Cells: A Cellular Pharmacology Agenda for mRNA Cancer Vaccines in Hematologic Malignancies

Morabito F, Martino Ea, Bruzzese A, Amodio N, Caserta S, Lucia E, Et Al.

mRNA-based vaccines are emerging as a promising platform for cancer immunotherapy, including in hematologic malignancies. Current vaccine development has largely focused on antigen selection, mRNA engineering, lipid nanoparticle (LNP) formulation, and combination with established immunotherapies. However, increasing…

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Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery

4. Rationally designed negatively charged lipid nanoparticles reduce systemic reactogenicity of mRNA vaccines while preserving immunogenicity

Karaki T, Inoue W, Gis T, Shichinohe S, Watanabe T, Hirai T, Et Al.

Messenger RNA (mRNA) vaccines have emerged as versatile platforms for the prevention of infectious diseases and therapeutic cancer vaccination. However, strong reactogenicity remains a key challenge, with severe adverse events such as myocarditis. These concerns may limit the applications of mRNA vaccines. As lipid…

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Nature Reviews Drug Discovery2024ReviewNon-viral Gene DeliveryDrug Delivery

5. The 60-year evolution of lipid nanoparticles for nucleic acid delivery

Pr Cullis, Pl Felgner

This historical review traces lipid-based gene delivery from cationic lipoplexes to ionisable lipid nanoparticles, connecting foundational research with approved mRNA vaccines and siRNA therapy.

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