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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

586 articles

Research Review

Showing 1–2 of 2 articles · Keyword: base editing Clear keyword

Biotechnology advances2026ReviewNon-viral Gene Delivery

1. From off-target to on-demand: Precision engineering and translational evaluation of next-generation base editors

Wang W, Song J, Du Y, Zhou C, Zuo X, You G, Et Al.

Due to the increasing demand for clinical gene therapy and the limitations of current treatment methods, there is an urgent need to develop gene-editing tools that are safer, more precise, and more clinically implementable. Deaminase-based base editors have emerged as gene-editing platforms with significant…

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Discover genetics and evolution2026ReviewNon-viral Gene Delivery

2. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies

Bhardwaj A

Off-target activity remains a significant challenge in the clinical development of CRISPR-based therapies. As programmable nucleases advance from experimental tools toward approved medicines, the ability to predict, detect, and mitigate unintended genomic editing events has acquired direct translational importance.

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