Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

616 articles

Research Review

Showing 1–2 of 2 articles · Keyword: guide RNA design Clear keyword

Progress in biophysics and molecular biology2026ReviewNon-viral Gene Delivery

1. AI-Enhanced CRISPR-Cas9 Therapeutics: Advances in Precision, Safety, and Delivery

Boretti A

CRISPR-Cas9 genome editing has transformed biomedical research and is advancing toward clinical translation. The integration of artificial intelligence (AI) offers improved precision in guide RNA design, off-target prediction, and delivery optimization. This review synthesizes recent advances in CRISPR-Cas9 for…

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Discover genetics and evolution2026ReviewNon-viral Gene Delivery

2. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies

Bhardwaj A

Off-target activity remains a significant challenge in the clinical development of CRISPR-based therapies. As programmable nucleases advance from experimental tools toward approved medicines, the ability to predict, detect, and mitigate unintended genomic editing events has acquired direct translational importance.

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