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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

406 articles

Keyword: host–guest complexClear keyword
Angewandte Chemie (International ed. in English)2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Supramolecular Pretargeting Lipid Nanoparticles Based on Host-Guest Recognition Potentiate Cancer Immunotherapy by Reprogramming Tumor Microenvironment

Gan J, Wang Y, Li M, Cui S, Zhu L, Yu X, Et Al.

Lipid nanoparticles (LNPs) have emerged as a promising platform for gene/drug delivery in cancer therapy, however their nonspecific biodistribution and extensive hepatosplenic sequestration result in insufficient intratumoral accumulation, thereby undermining the therapeutic efficacy. Here, we establish a sequential pretargeting strategy exploiting the high-affinity host-guest recognition between adamantane (ADA) and cucurbit[7]uril (CB[7]) to enhance tumor enrichment.

RNA deliveryhost–guest complexlipid nanoparticlessupramolecular chemistrytumor immunotherapy
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