Skip to content
Brilliant Blue Biosciences logoBrilliant BlueBiosciences
Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

406 articles

Keyword: supramolecular chemistryClear keyword
Angewandte Chemie (International ed. in English)2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Supramolecular Pretargeting Lipid Nanoparticles Based on Host-Guest Recognition Potentiate Cancer Immunotherapy by Reprogramming Tumor Microenvironment

Gan J, Wang Y, Li M, Cui S, Zhu L, Yu X, Et Al.

Lipid nanoparticles (LNPs) have emerged as a promising platform for gene/drug delivery in cancer therapy, however their nonspecific biodistribution and extensive hepatosplenic sequestration result in insufficient intratumoral accumulation, thereby undermining the therapeutic efficacy. Here, we establish a sequential pretargeting strategy exploiting the high-affinity host-guest recognition between adamantane (ADA) and cucurbit[7]uril (CB[7]) to enhance tumor enrichment.

RNA deliveryhost–guest complexlipid nanoparticlessupramolecular chemistrytumor immunotherapy
Read the article

Let's engineer the next delivery breakthrough together

We co-develop nanocarrier and biosensing programmes with pharma, biotech and academic groups — from target selection through GMP supply.

ResearchersRequest a technical consultationTalk formulation, characterisation or assay design with one of our scientists.Industry partnersExplore co-developmentFeasibility studies, co-development programmes, licensing and GMP supply.InvestorsDownload our capabilities deckPlatform, pipeline milestones, manufacturing and partnership models in one PDF.
Articles | Brilliant Blue Biosciences