Papers, explained in our own words

1. The Nanoparticle Delivery Gap in Immune Cell Engineering: From Uptake to Endosomal Escape

Gharatape A, Alikhanian A, Verdi J, Choonara Ye, Faridi-Majidi R

Although therapeutic opportunities beyond the scope of either field alone are offered by the combination of immune cell treatment and nanotechnology, a dominant nanoparticle design for immune-cell engineering has not been yielded by two decades of research. Here, it is contended that this lack of advancement is the result of a misdirected focus: endosomal escape, rather than cellular uptake, is held to be the actual rate-limiting stage in cytosolic distribution, even though cellular uptake is the target of most optimization efforts.