Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

421 articles

Keyword: non-viral deliveryClear keyword

International journal of nanomedicine2026ReviewDrug Delivery

1. The Nanoparticle Delivery Gap in Immune Cell Engineering: From Uptake to Endosomal Escape

Gharatape A, Alikhanian A, Verdi J, Choonara Ye, Faridi-Majidi R

Although therapeutic opportunities beyond the scope of either field alone are offered by the combination of immune cell treatment and nanotechnology, a dominant nanoparticle design for immune-cell engineering has not been yielded by two decades of research. Here, it is contended that this lack of advancement is the result of a misdirected focus: endosomal escape, rather than cellular uptake, is held to be the actual rate-limiting stage in cytosolic distribution, even though cellular uptake is the target of most optimization efforts.

CAR-T clinical translation endosomal escape immune cell therapy lipid nanoparticles nanoparticles non-viral delivery

Read the article

Advanced Materials2024ReviewNon-viral Gene Delivery

2. Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Cm Jogdeo, K Siddhanta, A Das, L Ding, S Panja, N Kumari, D Oupický

A review of polymer-based alternatives to lipid gene delivery, including polyplexes and polymer–nucleic acid conjugates, with attention to chemical tunability and clinical translation.

Polymeric gene delivery Polyplexes Nucleic acids Polymer conjugates Non-viral delivery Clinical translation Nanocarriers

Read the article

Let's engineer the next delivery breakthrough together

We co-develop nanocarrier and biosensing programmes with pharma, biotech and academic groups — from target selection through GMP supply.

ResearchersRequest a technical consultationTalk formulation, characterisation or assay design with one of our scientists.Industry partnersExplore co-developmentFeasibility studies, co-development programmes, licensing and GMP supply.InvestorsDownload our capabilities deckPlatform, pipeline milestones, manufacturing and partnership models in one PDF.