Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

406 articles

Keyword: clinical translationClear keyword

Frontiers in pharmacology2026ReviewDrug Delivery

1. Multi-target neuroprotective mechanisms of epigallocatechin-3-gallate (EGCG) in stroke: from molecular pathways to nanomedicine delivery and clinical translation

Yuan Y, Xie C, Huang Y, Xi J, Wang P, Chen Z, Et Al.

Stroke ranks among the leading global causes of mortality and permanent disability. Its secondary brain injury arises from multiple interrelated pathological cascades, including oxidative stress, neuroinflammation, disrupted autophagy-apoptosis balance, excitotoxicity, iron dyshomeostasis, and blood-brain barrier (BBB) dysfunction. Although intravenous thrombolysis and mechanical thrombectomy have greatly improved the efficacy of acute reperfusion therapy, effective neuroprotective regimens for secondary brain injury remain scarce.

EGCG clinical translation nanotechnology neuroprotection stroke

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Translational research : the journal of laboratory and clinical medicine2026ReviewDrug Delivery

2. Coupling Extracellular Vesicles with Nanomedicine for Precision Theranostics

Kausar T, Ahmed W, Shafiq T, Kausar R, Liang Y, Duan L

Nanomedicine represents one of the pivotal technologies that further bridges critical gaps in precision theranostics through targeted delivery, integrated diagnostics and therapeutics, and personalized treatment. Among various nanocarriers, extracellular vesicles (EVs) have attracted substantial interest owing to their nanoscale dimensions, favorable biocompatibility relative to synthetic counterparts, and innate capacity to transport bioactive cargoes.

Clinical Translation Extracellular Vesicles Precision Theranostics Standardization Surface Modification Therapeutic Cargo Delivery

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Advanced Materials2024ReviewNon-viral Gene Delivery

3. Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Cm Jogdeo, K Siddhanta, A Das, L Ding, S Panja, N Kumari, D Oupický

A review of polymer-based alternatives to lipid gene delivery, including polyplexes and polymer–nucleic acid conjugates, with attention to chemical tunability and clinical translation.

Polymeric gene delivery Polyplexes Nucleic acids Polymer conjugates Non-viral delivery Clinical translation Nanocarriers

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