1. Microenvironment-guided design of non-viral gene delivery systems: from biological cues to therapeutic translation
Mohammad Gholinia Sarpoli L, Hamblin Mr, Ebrahimifard M
Non-viral gene delivery systems offer adaptable alternatives to viral vectors for gene therapy. Nevertheless, their clinical translation remains limited by biological barriers and the pathological tissue microenvironment. Tumors exhibit alterations in the tissue microenvironment, including extracellular acidosis…
- non-viral gene delivery
- nucleic acid delivery
- pH-responsive systems
- redox-responsive systems
- stimuli-responsive nanocarriers
- tumor microenvironment
