Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–3 of 3 articles · Keyword: nucleic acid delivery Clear keyword

Nanomedicine (London, England)2026ReviewNon-viral Gene Delivery

1. Dual-vector nanoengineered mRNA-CRISPR delivery systems for precision gene therapy in choroidal melanoma

Thakur Sk, Malviya R, Chandra P, Sridhar Sb, Shareef J, Wadhwa T

Choroidal melanoma is the most common primary intraocular malignancy, and effective gene therapy remains limited by ocular barriers, tumor heterogeneity, and inefficient nucleic acid delivery. This review critically analyses the molecular rationale, engineering principles, emerging nanoarchitectures, biological…

Read the article

Expert opinion on drug delivery2026ReviewNon-viral Gene Delivery

2. Microenvironment-guided design of non-viral gene delivery systems: from biological cues to therapeutic translation

Mohammad Gholinia Sarpoli L, Hamblin Mr, Ebrahimifard M

Non-viral gene delivery systems offer adaptable alternatives to viral vectors for gene therapy. Nevertheless, their clinical translation remains limited by biological barriers and the pathological tissue microenvironment. Tumors exhibit alterations in the tissue microenvironment, including extracellular acidosis…

Read the article

Nature Reviews Drug Discovery2024ReviewNon-viral Gene DeliveryDrug Delivery

3. The 60-year evolution of lipid nanoparticles for nucleic acid delivery

Pr Cullis, Pl Felgner

This historical review traces lipid-based gene delivery from cationic lipoplexes to ionisable lipid nanoparticles, connecting foundational research with approved mRNA vaccines and siRNA therapy.

Read the article

Let's engineer the next delivery breakthrough together

We co-develop nanocarrier and biosensing programmes with pharma, biotech and academic groups — from target selection through scale-up.

ResearchersRequest a technical consultationTalk formulation, characterisation or assay design with one of our scientists.Industry partnersExplore co-developmentFeasibility studies, co-development programmes and licensing.InvestorsExplore the market opportunitySourced market sizes, pipeline, investment and deal data for genetic medicine delivery.