BioDrugs2026ReviewNon-viral Gene DeliveryDrug Delivery
1. Recent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier
U Iqbal, Rw Hwang, Wj Costain
A review of blood–brain barrier transport mechanisms and emerging lipid nanoparticle strategies for carrying nucleic acid and other complex therapies into the central nervous system.
- Blood-brain barrier
- Lipid nanoparticles
- CNS delivery
- Gene therapy
- mRNA
- siRNA
- Receptor-mediated transcytosis
