Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 1–7 of 7 articles · Keyword: Blood-brain barrier Clear keyword

International journal of nanomedicine2026ReviewDrug Delivery

1. An Update on Blood-Brain Barrier Penetrating Nanoparticles for the Treatment of Glioblastoma

Mcgranaghan Ct, Vankeulen-Miller R, Fenton Os, Mcerlean Em

Glioblastoma (GBM) is an aggressive and lethal primary brain malignancy, with patient survival largely unchanged over recent decades despite advances in surgery, radiotherapy and chemotherapy. A major therapeutic challenge is the blood-brain barrier (BBB), which restricts the delivery of many systemically…

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Current drug targets2026ResearchDrug Delivery

2. Nanomedicine Strategies for Brain-targeted Therapy in Neurological Disorders

Sharma S, Nag P, Vij K, Kalra A, Goel K

Neurological problems are among the world's most significant health issues. Many conditions are considered incurable because current treatments cannot effectively cross the Blood-Brain Barrier (BBB) to exert pharmacological effects. Nanomedicine utilizing various nanoparticles offers a distinct therapeutic approach…

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Current pharmaceutical design2026ResearchDrug Delivery

3. Rivastigmine and Emerging Nanotechnological Strategies for Targeted Delivery: A Comprehensive Review

Babar E, Ur Rehman A, Gul P, Arshad Ms, Shah Ba, Ahmed N

Alzheimer's disease affects millions of people globally; it is an irreversible and incurable disease, characterized by gradual cognitive decline as well as pathophysiological changes including the presence of senile plaques and neurofibrillary tangles. There are several risk factors associated with Alzheimer's…

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Current drug delivery2026ResearchDrug Delivery

4. Doxorubicin Nanocarriers in Glioblastoma Therapy: Advances and Limitations

Colpan Rd

Glioblastoma (GBM) remains one of the most aggressive brain malignancies, with limited therapeutic success largely due to the restrictive nature of the Blood-Brain Barrier (BBB) and intrinsic drug resistance mechanisms. Despite standard treatment strategies, the median survival remains approximately 16 months…

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International journal of nanomedicine2026ReviewDrug Delivery

5. Beyond Blood-Brain Barrier Crossing in Reperfusion-Era Ischemic Stroke: Interface-Matched Active-Entity Delivery and Translational Product Design

Bu F, Cao Y, Chen F, Wen Y, Xiong L

Reperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion, preservation of the blood-brain barrier and neurovascular unit (BBB/NVU), or durable neurological recovery. Nanomedicine is still commonly judged by BBB crossing or…

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Expert opinion on drug delivery2026ReviewDrug Delivery

6. Apolipoproteins in nanoparticle-mediated brain drug delivery: promise, mechanisms, and misconceptions

Gelperina S, Wacker Mg

Apolipoprotein E (apoE) plays a context-dependent role in nanomedicine for central nervous system drug delivery. It can facilitate cerebral endothelial recognition and increase brain exposure in nanoparticle systems while simultaneously promoting hepatic uptake, challenging its traditional interpretation as a…

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BioDrugs2026ReviewNon-viral Gene DeliveryDrug Delivery

7. Recent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier

U Iqbal, Rw Hwang, Wj Costain

A review of blood–brain barrier transport mechanisms and emerging lipid nanoparticle strategies for carrying nucleic acid and other complex therapies into the central nervous system.

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