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391 articles

Keyword: Protein expressionClear keyword

Molecular Therapy Methods & Clinical Development2025ReviewNon-viral Gene Delivery

1. Rational design of lipid nanoparticles for enabling gene therapies

Ca Brimacombe, Ja Kulkarni, Mhy Cheng, K An, D Witzigmann, Pr Cullis

A review of the physical principles and development history behind siRNA lipid nanoparticles for liver gene silencing and mRNA lipid nanoparticles for protein expression.

Lipid nanoparticles Gene therapy Rational design siRNA mRNA Liver delivery Protein expression

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