Acta pharmaceutica Sinica. B2026ResearchNon-viral Gene DeliveryDrug Delivery
1. Targeting cancer-associated neutrophils with biomimetic nano-vaccines loaded with mRNA can enhance the efficacy of immunotherapy for hepatocellular carcinoma
Li S, Zhang Y, Han Y, Zhao M, Wang Y, Lu J, Et Al.
Neutrophils exhibit significant plasticity within the tumor microenvironment (TME), such as promoting immune suppression, tumor growth, and metastasis. Although various nano drug delivery systems targeting neutrophils have been developed based on their tumor chemotaxis, few studies have focused on designing…
- Biomimetic carriers
- Cancer immunotherapy
- Reprogramming
- STING
- Tumor microenvironment
- Tumor-associated neutrophils (TAN)
- mRNA therapeutics
- mRNA vaccines