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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

601 articles

Research Review

Showing 1–2 of 2 articles · Keyword: epigenome editing Clear keyword

Epigenomics2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Synthetic mRNA engineering beyond prophylactic infectious disease vaccines: epigenomic and molecular reprogramming of diseased cells

Mustafa Am, Kareem Si, Raouf Cg, Ahmed Sm

The clinical validation of mRNA-based COVID-19 vaccines in 2020-2021 accelerated the development of synthetic messenger RNA as a precision therapeutic platform beyond infectious disease prevention. Unlike gene therapy approaches that permanently modify genomic DNA, synthetic mRNA enables transient protein expression…

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Discover genetics and evolution2026ReviewNon-viral Gene Delivery

2. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies

Bhardwaj A

Off-target activity remains a significant challenge in the clinical development of CRISPR-based therapies. As programmable nucleases advance from experimental tools toward approved medicines, the ability to predict, detect, and mitigate unintended genomic editing events has acquired direct translational importance.

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