Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

586 articles

Research Review

Showing 1–3 of 3 articles · Keyword: blood-brain barrier Clear keyword

International journal of nanomedicine2026ReviewDrug Delivery

1. Beyond Blood-Brain Barrier Crossing in Reperfusion-Era Ischemic Stroke: Interface-Matched Active-Entity Delivery and Translational Product Design

Bu F, Cao Y, Chen F, Wen Y, Xiong L

Reperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion, preservation of the blood-brain barrier and neurovascular unit (BBB/NVU), or durable neurological recovery. Nanomedicine is still commonly judged by BBB crossing or…

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Expert opinion on drug delivery2026ReviewDrug Delivery

2. Apolipoproteins in nanoparticle-mediated brain drug delivery: promise, mechanisms, and misconceptions

Gelperina S, Wacker Mg

Apolipoprotein E (apoE) plays a context-dependent role in nanomedicine for central nervous system drug delivery. It can facilitate cerebral endothelial recognition and increase brain exposure in nanoparticle systems while simultaneously promoting hepatic uptake, challenging its traditional interpretation as a…

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BioDrugs2026ReviewNon-viral Gene DeliveryDrug Delivery

3. Recent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier

U Iqbal, Rw Hwang, Wj Costain

A review of blood–brain barrier transport mechanisms and emerging lipid nanoparticle strategies for carrying nucleic acid and other complex therapies into the central nervous system.

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