Papers, explained in our own words

1. 19F MRI-Traceable PLGA Nanocarriers: Influence of Particle Architecture on Co-Encapsulation and Release of Immiscible Payloads

Larreina Vicente N, Lodrini A, Groeneveld E, Tagit O, Goumans Mj, Srinivas M

Two perfluorocarbon (PFC)-loaded PLGA nanoparticles (NPs) of different architectures were previously established as 19F MRI tracers: sodium cholate (NaCh)-stabilized core-shell particles (CSPs) and PVA-stabilized multicore particles (MCPs). Differing in their stabilizers and internal PFC distribution, they exhibited…

• controlled release
• image-guided drug delivery
• multiphasic systems
• particle architecture
• perfluorocarbons
• polymer nanoparticles
• theranostics

2. Current progress of self‑healing polymers for medical applications in tissue engineering

Self-healing polymers can repair damage and recover functionality, potentially extending the lifetime and safety of biomedical devices. Although self-healing hydrogels have been reviewed previously, papers focused specifically on their use in tissue engineering are scarce. This review summarises fabrication methods…

• Polymeric
• Hydrogels
• Drug delivery
• Chitosan
• Nanoparticles
• Controlled release
• Angiogenesis

3. Engineering a “PEG-g-PEI/DNA nanoparticle-in-PLGA microsphere” hybrid controlled release system to enhance immunogenicity of DNA vaccine

Yingxi Lu, Fapu Wu, Weihua Duan, Xueluer Mu, Sha Fang, Nana Lu, Xianfeng Zhou, Wei Kong

DNA vaccines require high doses because naked DNA is poorly delivered to antigen-presenting cells (APCs), and conventional PLGA microsphere encapsulation by W/O/W emulsion can damage DNA, lower supercoiled DNA content, and give low encapsulation efficiency. A controlled-release system is needed that protects DNA…

• DNA
• Polyethylenimine
• PLGA
• Controlled release
• Polymeric
• Transfection
• Macrophages

4. Morphologies and functionalities of polymeric nanocarriers as chemical tools for drug delivery A review

Venditti, I

Polymeric nanocarriers such as dendrimers, micelles, nanoparticles, nanogels, nanocapsules, and vesicles are widely investigated for drug delivery, but their morphology, surface chemistry, and functionalisation strongly influence drug loading, controlled release, and targeting. This review addresses the need for a…

• Polymeric
• Nanocarriers
• Drug delivery
• Nanoparticles
• Micelles
• Controlled release
• Gene delivery

5. Polymer–drug conjugate therapeutics advances, insights and prospects

Ekliadious, I.; Colson, Y. L.; Grinstaff, M. W

Polymer–drug conjugates have achieved clinical success, especially PEG–protein conjugates, but translation of many conjugates—particularly polymer–small-molecule anticancer therapeutics—remains limited. This review addresses the need for rational design, better understanding of in vivo barriers, and identification of…

• Polymeric
• Peptides
• Nanoparticles
• Biodistribution
• Micelles
• Controlled release
• Nanocarriers

6. Nanostructured Lipid Carriers A Novel Platform for Chemotherapeutics

Rizwanullah M, Ahmad J, Amin S

Conventional cancer chemotherapy suffers from poor drug specificity, narrow therapeutic windows, high dose-limiting toxicity, and multidrug resistance (MDR). Nanostructured lipid carriers (NLCs) are biocompatible, biodegradable lipid-based nanoparticles that can improve solubility, stability, targeting, and…

• Gene delivery
• Chemotherapy
• DNA
• Nanoparticles
• Controlled release
• Lipid nanoparticle
• Polymeric

7. Formulation and optimization of celecoxib-loaded PLGA nanoparticles by the Taguchi design and their in vitro cytotoxicity for lung cancer therapy

Jaber Emami, Aida Pourmashhadi, Hojat Sadeghi, Jaleh Varshosaz, Hamed Hamishehkar

COX-2 is overexpressed in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Celecoxib (Cxb), a COX-2 inhibitor, has antiproliferative and proapoptotic effects, but systemic administration carries cardiovascular risks. Pulmonary inhalation delivery of Cxb encapsulated in biodegradable PLGA…

• PLGA
• Nanoparticles
• Polymeric
• Controlled release
• Biodistribution
• Nanocarriers
• Gene delivery

8. (3-Aminopropyl)-4-methylpiperazine End-capped Poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based Multilayer Films for Gene Delivery

Cuicui Li, Stephany Y. Tzeng, Liane E. Tellier, Jordan J. Green

DNA-based therapeutics require an intracellular delivery system to be effective. For diseases like brain cancer—where local access to residual tumour is often available following surgical resection—an implantable device that enables both controlled release and intracellular delivery of DNA could open new…

• Gene delivery
• Polymeric
• DNA
• Transfection
• Poly(beta-amino ester)
• Controlled release
• Endosomal escape

9. Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: low burst release is crucial for efficient CD8⁺ T cell activation

A.L. Silva, R.A. Rosalia, A. Sazak, M.G. Carstens, F. Ossendorp, J. Oostendorp, W. Jiskoot

Overlapping synthetic long peptides (SLPs) are promising for therapeutic cancer vaccination, but Montanide-based formulations have limitations including non-biodegradability, local side effects, poorly controlled release, and limited scalability. PLGA nanoparticles (NPs) offer a biodegradable alternative, but…

• T cells
• PLGA
• Nanoparticles
• Antigen presentation
• Controlled release
• Peptides
• Polymeric

10. Polymeric nanoparticles for cancer therapy

Parveen, S.; Sahoo, S. K

Conventional cancer chemotherapy suffers from poor tumour selectivity, high required doses, systemic toxicity, rapid drug elimination, and multidrug resistance. Polymeric nanoparticles (NPs) are reviewed as a strategy to improve targeted delivery, controlled release, and therapeutic efficacy while reducing adverse…

• Polymeric
• Nanoparticles
• PLGA
• Cellular uptake
• Targeted delivery
• Controlled release
• Micelles

11. Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine

Xianfeng Zhou, Bin Liu, Xianghui Yu, Xiao Zha, Xizhen Zhang, Yu Chen, Xueyun Wang, Yinghua Jin, Yongge Wu, Yue Chen, Yaming Shan, Yan Chen, Junqiu Liu, Wei Kong, Jiacong Shen

DNA vaccines can induce antibody and CTL responses, but clinical translation is limited by weak potency and the need for high or repeated doses. The study addresses this by targeting DNA to antigen-presenting cells (APCs) and improving endosomal/lysosomal release, using mannose-bearing chitosan microspheres loaded…

• DNA
• Chitosan
• Polyethylenimine
• Controlled release
• Transfection
• Dendritic cells
• Macrophages

12. Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes

Norbert Dinauer, Sabine Balthasar, Carolin Weber, Jörg Kreuter, Klaus Langer, Hagen Von Briesen

Antibody-based therapeutics have shown promise in targeting specific cell types, but their efficacy can be enhanced by conjugation to drug carriers. Nanoparticles as drug carriers offer advantages including high drug loading capacity, controlled release, and protection from degradation. However, achieving selective…

• Nanoparticles
• T cells
• Endocytosis
• Cellular uptake
• Drug delivery
• Targeted delivery
• Controlled release